Position a rack in the lower third of the oven and preheat to 425°F (220°C). Roll out homemade crust and fit into a 9-inch pie dish, then crimp the edges.
Prick the crust base all over with a fork, line with parchment, and fill with pie weights or dried beans. Par-bake for 10 minutes, then remove weights and parchment and set aside.
In a large mixing bowl, whisk together granulated sugar, brown sugar, cinnamon, ginger, nutmeg, cloves, and salt. Break up any brown sugar lumps.
Crack in the room-temperature eggs and whisk until glossy and slightly loose. Add the full can of pumpkin puree and vanilla, whisking until fully blended with no dry streaks.
Pour in the evaporated milk gradually while whisking until the filling is completely smooth and pourable, about 30 seconds. The filling will look thin at this stage.
Set the par-baked crust on a rimmed baking sheet. Pour the filling into the shell, stopping just below the rim to avoid overflow.
Bake at 425°F (220°C) for 15 minutes. Reduce oven to 350°F (175°C), cover the crust edge with foil or a shield, and bake for 40 to 45 minutes more.
The pie is done when the edges are set but the center still jiggles slightly like set jelly. An instant-read thermometer inserted an inch from the center should read about 175°F (79°C).
Transfer the pie to a wire rack and let it cool at room temperature for at least 3 hours. The custard continues to set as it cools. Slice into 8 wedges and serve.