Preheat the oven to 350°F (175°C). Lightly grease a 9x13-inch (23x33 cm) baking dish with butter or nonstick spray, getting into the corners.
Open both cans of lemon pie filling and spread all of it evenly across the bottom of the greased dish. Use a spatula to push the filling into the corners so the base is level from edge to edge.
In a medium bowl, beat the softened cream cheese with a hand mixer or whisk until smooth and lump-free. Add the powdered sugar, egg, vanilla, and lemon zest if using, then beat again until creamy and pourable, about 1 minute.
Drop spoonfuls of the cream cheese mixture over the lemon filling, spacing them across the whole pan. Gently spread the dollops with a spatula so they connect into a rough layer, without stirring them into the lemon filling underneath.
In a separate bowl, pour in the entire box of cake mix. Add the melted butter and stir with a fork until the mixture looks like damp, clumpy crumbs with no dry powder left.
Scatter the buttered cake mix crumbs evenly over the cream cheese layer. Break up any large clumps with your fingers and cover the surface as completely as you can, since even coverage is what gives you a uniform crust.
Bake for 38 to 45 minutes, until the top is golden brown and the lemon filling bubbles up around the edges. If the center still looks pale at 40 minutes, give it a few more minutes; the edges will darken first.
Let the cake rest for at least 15 to 20 minutes out of the oven. The filling sets slightly as it cools, which makes it much easier to scoop into clean servings.